循環器病レクチャー
最終更新日 09/09/00
Web上で循環器の研究・臨床の各分野のエキスパートから、臨床医のためのレクチャーをしていただくという企画の第２弾です。
Kaplanの高血圧教科書のReferenceにも引用されるほど２次性高血圧の豊富な症例を経験され、高血圧、臨床薬理学ご専門の北海道薬科大学 病態生理生化学の野村憲和教授にレクチャーいただくことになりました。ともすれば看過しがちな２次性高血圧の臨床的要点をレクチャーいただきます。
野村 憲和（のむら あきかず）教授のプロファイル
|
|
|
|
昭和４９年３月 |
北海道大学医学部卒業 |
|
昭和４９年４月 |
北海道大学医学部循環器内科に入局 |
|
昭和５７年９月 |
米国オクラホマ大学医学部薬理学教室研究員 |
|
昭和５９年３月 |
帰国 |
|
昭和６０年１月 |
北海道大学医学部循環器内科助手 |
|
平成 ７年２月 |
北海道大学医学部循環器内科講師 |
|
平成１０年８月 |
北海道大学医学部循環器内科助教授 |
|
平成１１年４月 |
北海道薬科大学 大学院薬学研究科教授（病態生理生化学） |
|
|
|
|
日本臨床薬理学会評議員 |
|
|
国際高血圧学会会員 |
|
１． Effect of furosemide in
congestive heart failure Clin Pharmacol Ther 30(2):177-182 (1981.8) Akikazu Nomura, Hisakazu Yasuda,
Masaru Mimami, Tsugio Akimoto, Katsumi Miyazaki,
and Takaichi Arita ２． Hydralazine and furosemide
kinetics Clin Pharmacol Ther 32(3):303-306 (1982.9) Akikazu Nomura, Hisakazu Yasuda,
Kunihiko Katoh, Tsugio Akimoto, Katsumi Miyazaki,
and Takaichi Arita ３． Acute and chronic effects of
verapamil in patients with paroxysmal
supraventricular tachycardia Am Heart J 105(4):619-628 (1983.4) Masayuki Sakurai, Hisakazu
Yasuda, Noriyoshi kato, Akikazu Nomura, Miri
Fujita, Tetsuo Nishino, Kosuke Fujita, Yuichi
Koike, and Hideya Saito ４． CNS adrenergic inhibition of
parasympathetic oculomotor tone J Autono Nerv Syst 10(1):55-68 (1984.1) Michael C koss, Tseggai
Gherezghiher, and Akikazu Nomura ５． High-performance liquid
chromatographic determination of nifedipine in
plasma J Chromatogr 310:219-222 (1984) Katsumi miyazaki, Naonori Kohri,
Takaichi Arita, Hisashi Shimono, Kunihiko Katoh,
Akikazu Nomura, and Hisakazu Yasuda ６． Direct blood pressure monitoring
in patients with pheochromocytoma Jpn H J 26(5):845-850 (1985.9) Akikazu Nomura, Hisakazu Yasuda,
Kunihiko Katoh, Hisashi shimono, Takeshi Murakami,
Masaru Minami, and Shigeru Takechi ７． Release characteristics of
nifedipine sustained-release granules in vitro and
in healthy subjects Chem Pharm Bull 35(6):2504-2509 (1987.6) Naonori Kohri, Katsumi Miyazaki,
Takaichi Arita, Hisashi Shimono, Akikazu Nomura,
and Hisakazu Yasuda ８． Cardiac acetylcholine
concentration in the mouse. Life Sciences 43(9):801-805 (1988.8) A.Nomura, H.Yasuda, H.Shimono,
S.Takechi, and Y.Maruyama ９． Cardiac acetylcholine
concentration in the rat. Life Sciences 47(2):135-139 (1990.7) A. Nomura, H. Yasuda, S.
Takechi, H. Matsuo and Y. Maruyama １０． Contineous blood pressure
recordings in patients with pheochromocytoma of the
urinary bladder Am J Hypertension 4(2):189-191 (1991.2) Akikazu Nomura, Hisakazu Yasuda,
Kunihiko Katoh, Shigeo Kakinoki, Shigeru Takechi,
Takeshi Kobayashi, and Hisashi Shimono １１． A simple method for the
simulation of unbound serum disopyramide
concentration in patients J Pharmacobio Dyn 14(9):493-499 (1991.9) Satoshi kishino, Naonori Kohri,
Ken Iseki, Katsumi Miyazaki , Akikazu Nomura, and
Hisakazu Yasuda. １２． Serun alpha-1-acid glycoprotein
and disopyramide protein binding in patients with
congestive heart failure. Europ J Clin Pharmacol 42(1):115-116
(1992.1) A. Nomura, H. Yasuda, T.
Kobayashi, S. kishino, N. Kohri, K. Iseki, and K.
Miyazaki １３． Evaluation of pH-independent
sustained-release granules of dipyridanole by using
gastric-acidity-controlled rabbits and human
subjects Int J Pharm 80(1):49-58 (1992.4) Naonori Kohri, Natsumi Miyata,
Masaki Takahashi, Harumi Endo, Ken Iseki, Katsumi
Miyazaki, Shigeru Takechi, and Akikazu
Nomura １４． Rapid and simple determination
method of α-1-acid glycoprotein in the serum by
high- performance liquid chromatography J Chromatogr 582(2):246-248 (1992.10) Satoshi kishino, Zhai S.Di,
Mitsuru Sugawara, Ken Iseki, Katsumi Miyazaki,
Shigeru Kakinoki, Akikazu Nomura, and Akira
Kitabatake １５． Enantioselective
pharmacokinetics of homochlocyclizine II: the
disposition and metabolism of (+)-,(-)- and racemic
homochlocyclizine afer oral administration to
man Europ J Clin Pharmacol 43(11):533-538
(1992.11) M. Nishikata, A. Nomura, K.
Iseki, K. Miyazaki, A. Nakai, H. Fushida, K.
Miyake, and T. Arita １６． Enantioselective
pharmacokinetics of homochlocyclizine
III:Simultaneous determination of (+)- and (-)-
homochlocyclizine in human urine by
high-performance liquid chromatography J chromatogr 612(2):239-244 (1993.2) Mayumi Nishikata, Aki Nakai,
Hitomi Fushida, Keishiro Miyake, Takaichi Arita,
Ken Iseki, Katsumi Miyazaki, and Akikazu
Nomura. １７． Digoxin dose adjusted according
to estimated creatinine clearance in elderly
patients with cardiac disease Cardiol Elderly 2(2):139-143 (1994.4) Akikazu Nomura, Akira
Kitabatake, Satoshi Kishino, Ken Iseki, and Katsumi
Miyazaki １８． Altered alpha-1-acid
glycoprotein concentration and free fraction of
disopyramide in patients with heart
disease Jpn J Clin Pharmacol Ther 25(2):413-418
(1994.6) Akikazu Nomura, Akira
Kitabatake, Satoshi Kishino, Zhai S.DI, Ken Iseki,
and Katsumi Miyazaki １９． Alpha-1-acid glycoprotein
concentration and the protein binding of
disopyramide in healthy subjects J Clin Pharmacol 35(5):510-514 (1995.5) Satoshi Kishino, Akikazu Nomura,
Zhai Suo Di, Mitsuru Sugawara, Ken Iseki, Shigeo
Kakinoki, Akira Kitabatake,and Katsumi
Miyazaki ２０． Changes in the binding capacity
of alpha-1-acid glycoprotein in patients with renal
insufficiency Ther drug monitor 17(5):449-453 (1995.9) Satoshi Kishino, Akikazu Nomura,
Zhai Suo Di, Mitsuru Sugawara, Ken Iseki, Shigeo
Kakinoki, Akira Kitabatake,and Katsumi
Miyazaki ２１． Purification method for
α-1-acid glycoprotein with subsequent
high-performance liquid chromatographic
determination of monosaccharides in plasma of
health subjects and patients with renal
insufficiency J Chromatogra B 672:199-205 (1995.11) Satoshi Kishino, Akikazu Nomura,
Mitsuru Sugawara, Ken Iseki, Shigeo Kakinoki, Akira
Kitabatake,and Katsumi Miyazaki ２２． Effects of doxazosin on
orthostatic blood pressure in hypertensive patients
with and without diabetes mellitus Curr Ther Res 57(6):411-417 (1996.6) Akikazu Nomura, Shigeo Kakinoki,
Masayuki Sakurai, Takayuki Hirabayashi ,Masashi
Nakamura, Keiji Yoneya, Keiichiro Imamura, and
Akira Kitabatake ２３． Physical activity affects
ambulatory blood pressure in normotensive and
hypertensive elderly people Cardiol Elderly 4(2/3):101-104 (1996.6) Akikazu Nomura, Shigeo Kakinoki,
Shigeru Takechi, Hisashi Shimono, Kazuo Tomita,
Masayuki Sakurai, and Akira Kitabatake ２４． A single-step isolation method
for six glycoforms of human α-1-acid glycoprotein
by hydroxyapatite chromatography and study of their
binding capacities for disopyramide J Chromatogra B 703(1):1-6 (1997.12) Satoshi Kishino, Akikazu Nomura,
Michiyo Saitoh, Mitsuru Sugawara, Ken Iseki, Akira
Kitabatake,and Katsumi Miyazaki ２５． How a dihydropyridine calcium
channel blocker, benidipine, acts on ambulatory
blood pressure influenced by daily physical
activity J Hum Hyperten 11(12):823 (1997.12) Akikazu Nomura, Shigeo Kakinoki,
Shigeru Takechi, and Akira Kitabatake ２６． Malignant cardiac
pheochromocytoma with bone metastases Circulation 97(19):1993-1994 (1998.5) Akikazu Nomura, Shigeo Kakinoki,
Miri Fujita and Akira Kitabatake ２７． Fibromuscular dysplasia
involuving coronary arteries Angiology 50(2):153-156 (1999.2) Takanori Ogawa, Akikazu Nomura,
Hiroshi Komatsu, Satoshi Fujii, Kazushi Urasawa
Hiroshi Okamoto and Akira Kitabatake ２８． Recovery of cardiac
norepinephrine concentration and tyrosine
hydroxylase activity by central
alpha-2-adrenoceptor agonist guanabenz in rat with
aortic constriction J Cadiovasc Pharmacol 33(3):409-413 (1999.3) Shigeru Takechi, Akikazu Nomura,
Hisashi Shimono, Kunihiko Katoh, Shigeo Kakinoki,
En-Ze Jin, Mitsuyuki Akutsu, and Akira
Kitabatake ２９． Effects of short-acting and
long-acting calcium channel blockers on the
relationship between blood pressure and physical
activity Am J Hyperten (impress) (2000) Shigeo Kakinoki, Akikazu Nomura,
Shigeru Takechi, and Akira Kitabatake
ここをクリックするとMedlineで野村憲和先生の文献の一部の要約がご覧になれます（ただし検索上、同姓で同名のイニシャルの場合がありますのでご容赦ください）。
最後にはなりますが、北海道薬科大学 病態生理生化学教室の今後の更なるご発展と、野村憲和先生のますますのご活躍を期待してご紹介にかえさせていただきます。
